Design, Synthesis and Characterization of 1,2-Phenylenediamine Functionalized Poly (Maleic Anhydride-alt-Vinyl Acetate) as a Potential New Bioactive Formulation

Authors : Gülderen KARAKUŞ

Pages : 305-311

Doi:10.17350/HJSE19030000284

View : 15 | Download : 10

Publication Date : 2022-12-31

Article Type : Research Paper

Abstract :This study includes the design, synthesis and characterization of 1,2-phenylenediamine insert ignore into journalissuearticles values(o-PDA); functionalized maleic anhydride insert ignore into journalissuearticles values(MA);-vinyl acetate insert ignore into journalissuearticles values(VA); copolymer-based conjugate to develop a new formulation. The 1,2-phenylenediamine molecule is a fluorescent dye that allows designing new chemotherapeutic polymeric molecules. Polyinsert ignore into journalissuearticles values(maleic anhydride-alt-vinyl acetate); [Polyinsert ignore into journalissuearticles values(MA-alt-VA);] was obtained via charge transfer complex insert ignore into journalissuearticles values(CTC); radical polymerization presence of methyl ethyl ketone insert ignore into journalissuearticles values(MEK);, utilizing benzoyl peroxide insert ignore into journalissuearticles values(BPO); free-radical initiator at 80 °C, as a potential functional polymeric carrier. Structural characterization of the surface functionalized polyinsert ignore into journalissuearticles values(MA-alt-VA);/1,2-PDA conjugate was performed by Attenuated Total Reflectance-Fourier Transform Infrared insert ignore into journalissuearticles values(ATR-FTIR); and Nuclear Magnetic Resonance insert ignore into journalissuearticles values(1H-NMR);. Spectroscopic methods and water solubility results confirmed that the conjugation took place successfully after the ring opening reaction by the amidation mechanism.
Keywords : poli MA alt VA, Surface modification, 1, 2 phenylenediamine, ATR FTIR, 1H NMR