Simple Sensor Application: Determination of Electrochemical Properties of Carvedilol in CPE Based on Zinc Oxide Nanoparticles and Development of the Method for its Determination in Pharmaceutical Samples

Authors : Emre GÜVEN, Funda ÖZTÜRK

Pages : 43-48

Doi:10.17350/HJSE19030000289

View : 14 | Download : 10

Publication Date : 2023-03-31

Article Type : Research Paper

Abstract :In the study, the electrochemical characteristics of carvedilol were determined by cyclic voltammetry and square wave voltammetry on carbon paste electrode with zinc oxide nanoparticles at pH 8.0 in Britton Robinson buffer. The adsorption characteristics of the molecule on the modified electrode and the electron number accompanying the electrode reaction were calculated. In addition, a new square wave anodic adsorptive stripping voltammetry process was suggested for the determination of carvedilol drug samples. The linear concentration range and detection limit of the process were found to be 0.07 µM–2.61 µM and 0.09 µM, respectively. Recovery studies of CAR in the pharmaceutical sample were performed to check the accuracy of the developed process. With the developed process, results with high reliability, reproduceability, accuracy and precision were obtained for the determination of CAR in pharmaceutical samples.
Keywords : carbon paste elecreode, carvedilol, tablet, stripping voltammetry, zinc oxide nanoparticles