Prognostic factors after pneumonectomy in non-small cell lung cancer

Authors : Cemal AKER, Celal Buğra SEZEN, Mustafa Vedat DOĞRU, Ali Murat AKÇIL, Umut KİLİMCİ, Semih ERDUHAN, Levent CANSEVER, Muzaffer METİN

Pages : 6-12

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Publication Date : 2022-01-31

Article Type : Research Paper

Abstract :Background: This study aims to evaluate the factors affecting survival and mortality in patients who underwent pneumonectomy for non-small cell lung cancer. Methods: The study included 241 pneumonectomy patients. Demographic data, mortality, histopathological characteristics, tumor stages, and 5-year survival rates were analyzed. Results: The study included nine women (3.7%) and 232 men (96.3%). The patients’ mean age was 58.4±8.0 (34–81) years. Fortyfive patients (18.7%) were 65 years of age or older, and 196 patients (81.3%) were less than 65 years of age. The 30-day postoperative mortality rate was 7.9% (n=19). The only factor affecting mortality was determined as age 65 and over (p = 0.012). The median survival time was 52 months, and the 5-year survival rate was 49.4%. In multivariate analysis, advanced age, pN2 status, not receiving neoadjuvant treatment, performing sampling lymph node dissection, and not receiving adjuvant treatment were poor prognostic factors. Conclusion: Age, pN2 status, neoadjuvant and adjuvant therapy, and lymph node dissection technique were determined as the most important prognostic factors affecting survival in patients who underwent pneumonectomy for non-small cell lung cancer. Age was the most important factor affecting mortality.
Keywords : Prognosis, Pneumonectomy, Survival Rate, Carcinoma, Non Small Cell Lung

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