in vitro Study of Antidiabetic Effect of Abrus precatorius Methanol Leaves Extract against Glucose Absorption

Authors : Hafedh ALMOALEMİ, Wahid ALTOWAYTİ, Siti Pauliena MOHD BOHARİ

Pages : 117-126

Doi:10.38001/ijlsb.701093

View : 22 | Download : 15

Publication Date : 2020-08-15

Article Type : Research Paper

Abstract :Diabetes mellitus is a common chronic systemic disorder characterised by hyperglycaemia as a standard feature. A traditional plant known as Abrus precatorius insert ignore into journalissuearticles values(AP); has been used for the treatment of type II diabetes mellitus in Malaysia. The potential of the 80% methanolic extract of A. precatorius leaves has been tested in vitro for its α-glucosidase inhibition and its glucose diffusion activity. It was observed that the extraction of A. precatorius leaves exhibit a high α-glucosidase inhibition at the concentrations of 25 and 50 mg/mL insert ignore into journalissuearticles values(65.4% and 84.6%);, respectively, but low inhibition at the concentration of 6.25 to 12.5 mg/mL insert ignore into journalissuearticles values(25% and 28.2%); when compared to control. Meanwhile, the methanolic extract of A. precatorius slightly affected the glucose diffusion at the concentration of 50 mg/mL insert ignore into journalissuearticles values(9.5%); within 24 h compared to the control group. These results indicated that the methanolic extract of A. precatorius leaves is capable of inhibiting α-glucosidase activity, besides halting glucose diffusion activity by delaying the glucose absorption in the gut.
Keywords : Abrus precatorius, Diabetes mellitus, Acarbose, Alpha glucosidase, Glucose diffusion