Evaluation of MMP2, Caspase-3 and C-Kit Expression on Thyroid Papillary Cancer Prognosis

Authors : Arzu BOZTAŞ, Hakan BULUŞ, Gülçin GÜLER ŞİMŞEK, Altan AYDIN, Arzu KOÇDOĞAN, Volkan ATEŞ, Serpil OĞUZTÜZÜN

Pages : 23-32

Doi:10.47947/ijnls.915634

View : 21 | Download : 8

Publication Date : 2021-06-01

Article Type : Research Paper

Abstract :A number of new molecular and genetic factors are currently being studied in determining the prognosis of thyroid papillary carcinoma. In our study, we aimed to determine if there was a relationship between prognostic factors and expression of Matrixmatalloproteniase 2 insert ignore into journalissuearticles values(MMP-2);, the tyrosine-kinase receptor CD117 insert ignore into journalissuearticles values(c-kit); and caspase-3. MMP2, c-kit and caspase-3 by immunohistochemical insert ignore into journalissuearticles values(IHC); method were studied in both intact and pathological tissue of the thyroid gland removed after surgery in patients with thyroid papillary cancer. Prognostic factors such as age, histological stage, extrathyroidal spread, metastasis, tumor size were also evaluated. There was no statistically significant difference between prognosis and c-kit, MMP-2 and caspase-3 expression in patients insert ignore into journalissuearticles values(p>0.05);. Clinicopathological parameters were thought to be more important than c-kit, caspase 3 and MMP2 in predicting prognosis in thyroid papillary cancers.
Keywords : Thyroid papillary carcinoma, MMP 2, C kit, Caspase 3