GST-Theta1 Enzyme Expression Levels in Brain Tumor and Their Relationship with the Clinical Data of the Patients

Authors : Onur DİRİCAN, Pınar KAYGIN, Sezen YILMAZ SARIALTIN, Can YILMAZ, Volkan ATEŞ, Gülçin GÜLER ŞİMŞEK, Serpil OĞUZTÜZÜN, Tülay ÇOBAN, Yusuf İZCİ
Pages : 82-98
Doi:10.47947/ijnls.1016468
View : 40 | Download : 15
Publication Date : 2021-12-01
Article Type : Research Paper
Abstract :The most important drug metabolizing enzyme of the detoxification mechanism is known as Glutathione S-Transferase. GST enzymes may be associated with brain tumor epidemiology, clinical and demographic factors. The correlation between parameters such as changes in Glutathione S-transferase Theta1 proteins, tumor localizations, age, gender, alcohol use, smoking, chemotherapeutic/radiotherapeutic treatment status in normal and brain tumor tissues, diagnosed in neurosurgery department, were examined by immunohistochemistry. GST-Theta1 expressions were analyzed using immunostaining in samples from 149 patients diagnosed with brain tumors between 2016 and 2018. The mean age of the patient group was 49.44 years. 83 insert ignore into journalissuearticles values(58.45%); patients were male. After immunohistochemical staining, GST-T1 expression was found approximately 9,46 times higher in tumor tissues than in normal tissues insert ignore into journalissuearticles values(p<0.0001);. Tumor tissues from patients who received chemotheraphy showed higher expression of GST-T1 than those who did not insert ignore into journalissuearticles values(p<0,05);. In addition, GST-T1 expression level was observed at a significantly higher level in patients younger than 60 years of age compared to patients over 60 years insert ignore into journalissuearticles values(p<0.026; p<0.05);. There was no statistically significant relationship between patients smoking behaviors, alcohol consumption, tumor localization and GST-T1 expressions. It is aimed to determine the GST-T1 protein expressions and to contribute to the examination of epidemiological and prognostic factors of brain tumors by comparing them with demographic and clinical data.
Keywords : Brain Cancer, Immunohistochemistry, Glutation S Transferase, GST T1

ORIGINAL ARTICLE URL