Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro

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International Journal of Secondary Metabolite
Volume:4 Issue:3, Special Issue:2 Special Issue
Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro

Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro

Authors : Ramazan ERENLER, İbrahim DEMİRTAS, Tunay KARAN, Muhammed ALTUN, Fatih GUL

Pages : 512-516

Doi:10.21448/ijsm.377767

View : 17 | Download : 10

Publication Date : 2017-12-20

Article Type : Research Paper

Abstract :Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa insert ignore into journalissuearticles values(human cervix carcinoma); cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.
Keywords : Kickxia spuria, flavone, HeLa

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