Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes

Authors : Hülya ÇELİK, Aynur BABAGİL

Pages : 38-48

Doi:10.21448/ijsm.479108

View : 13 | Download : 14

Publication Date : 2019-03-16

Article Type : Research Paper

Abstract :In this study, N-benzylidene-4-fluoroaniline insert ignore into journalissuearticles values(3a);, N-benzylidene-4-nitroaniline insert ignore into journalissuearticles values(3b); as a result of condensation of benzaldehyde insert ignore into journalissuearticles values(1); and 4-fluoroaniline insert ignore into journalissuearticles values(2a);, 4-nitroaniline insert ignore into journalissuearticles values(2b); using a microwave method was synthesized. The structures of the synthesized compounds were characterized by Fouirer Transform İnfrared Spektrofotometre insert ignore into journalissuearticles values(FTIR spectroscopy);, Nuclear Magnetic Resonance insert ignore into journalissuearticles values(NMR spectroscopy); and elemental analysis methods. The prepared compounds were tested for their inhibitory effects on carbonic anhydrase isoenzymes insert ignore into journalissuearticles values(hCA-I and hCA-II);. The results showed that the synthesized compounds 3a and 3b had a strong inhibitory effect on hCA-I and hCA-II enzymes activity in vitro. By testing these compounds in other CA isoenzymes, more effective CA inhibitors can be formed. Thus, new therapeutic applications can be made for enzyme activators in the near future.
Keywords : Schiff, Microwave, Fluoroaniline, Nitroaniline, Inhibitor