Synergistic antibacterial evaluation of Coriandri aetheroleum and linalool with standard antibiotics

Authors : Gözde ÖZTÜRK, Gamze GÖGER, Fatih DEMİRCİ, Betül DEMİRCİ

Pages : 323-331

Doi:10.21448/ijsm.1140803

View : 138 | Download : 112

Publication Date : 2023-08-27

Article Type : Research Paper

Abstract :Within this work, it was aimed to investigate the in vitro antibacterial properties of the Pharma grade coriander insert ignore into journalissuearticles values(Coriandrum sativum L.); essential oil, and its combinations. The chemical composition of the essential oil was confirmed by gas chromatography insert ignore into journalissuearticles values(GC); and gas chromatography-mass spectrometry insert ignore into journalissuearticles values(GC-MS); analyses, simultaneously. Furthermore, the potential antibacterial activity of both the essential oil, and insert ignore into journalissuearticles values(+);-linalool with standard compounds chloramphenicol, and ciprofloxacin were evaluated using an in vitro microdilution assay against a panel of selected pathogens, namely Acinetobacter baumannii, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Initially, the minimum inhibitory concentrations insert ignore into journalissuearticles values(MIC); were determined, the essential oil as well as insert ignore into journalissuearticles values(+);-linalool and the standard antibiotics were combined for the synergistic antibacterial activity potential, where the combination activities were expressed as fractional inhibitory concentration index values insert ignore into journalissuearticles values(Σ FIC);. The Coriander oil was relatively more effective against B. cereus, P. aeruginosa, E. coli, A. baumannii insert ignore into journalissuearticles values(2500 µg/mL); compared to S. aureus insert ignore into journalissuearticles values(5000 µg/mL);, respectively. insert ignore into journalissuearticles values(+);- Linalool was found as effective as the essential oil insert ignore into journalissuearticles values(2500-5000 µg/mL);. Coriander oil and antibiotic combinations showed synergistic effects against B. cereus insert ignore into journalissuearticles values(∑FIC= 0.375);, E. coli insert ignore into journalissuearticles values(∑FIC= 0.078); and S. aureus insert ignore into journalissuearticles values(∑FIC= 0.375);. Combination with insert ignore into journalissuearticles values(+);-linalool, and antibiotics showed synergistic effects against B. cereus insert ignore into journalissuearticles values(∑FIC= 0.375);, E. coli insert ignore into journalissuearticles values(∑FIC= 0.093);, as well as against S. aureus insert ignore into journalissuearticles values(∑FIC= 0.375);, respectively. To the best of our knowledge, this is the first time of the antimicrobial combination study of linalool, coriander oil, chloramphenicol, and ciprofloxacin. The initial findings of this work suggest further natural product and drug combination evaluations.
Keywords : Coriander, Apiaceae, Linalool, in vitro antibacterial activity, synergy