Novel carbazole alkaloid from Murraya koenigii (l.) Spreng

Authors : Arifa MEHREEN, Shagufta KAMAL, Sevinc MUSAYEVA, Muhammad QAİSAR, Sumia URAİNAB, Asad ULLAH

Pages : 354-360

Doi:10.21448/ijsm.1193419

View : 66 | Download : 62

Publication Date : 2023-08-27

Article Type : Research Paper

Abstract :Background: The plant Murraya koenigii insert ignore into journalissuearticles values(L.); Spreng.native to Pakistan and India and a part of the Rutaceae family, plays a vital role in the Indian Ayurvedic medicine system. Studies have shown that this plant\`s bark, roots, and leaves contain many carbazole alkaloids. These alkaloids are known to have substantial therapeutic properties. Methods: The crushed and powdered organs of M. koenigii were extracted with several solvents insert ignore into journalissuearticles values(acetone, chloroform, and methanol);. Then, using column chromatography, a dull brown oily substance, MK- 1 insert ignore into journalissuearticles values(1.05 g);, was obtained with chloroform and methanol insert ignore into journalissuearticles values(7:3);. Result We have successfully isolated a new carbazole alkaloid, 3-geranyl 8-hydroxy 6, 7-di methoxy 3’, 3’-dimethyl 1, 2-pyranocarbazole, from the seeds of M. koenigii. The structure was further elucidated by cross-referencing our NMR, UV, IR, and MS data with that found in the published literature. Conclusion: Comparing the previously published literature data clearly explained that this alkaloid is new to M. koenigii.
Keywords : Murraya koenigii, Rutaceae, Carbazole alkaloid, Pyranocarbazole