Analysis of Trace Elements in FFPE Colon Tissue Specimens Using ICP-MS

Authors : Omer Faruk KOCAK, Mevlut ALBAYRAK

Pages : 10-14

View : 23 | Download : 15

Publication Date : 2021-07-15

Article Type : Research Paper

Abstract :The aim of this study was to reveal the relationship of colon cancer with some trace elements insert ignore into journalissuearticles values(Cr, Mn, Co, Ni, Cu, Zn, Se, Ag, Cd and Pb); and to end the contradictory results of previous studies on this subject. We wanted to eliminate the sampling and method errors shown as the cause of these contradictions. In this study, FFPE insert ignore into journalissuearticles values(Formalin-fixed paraffin embedded); cancer colon tissues of 12 patients with a diagnosis of colon cancer aged between 35 and 75 years and healthy colon tissues of the same people were used. The results of the analysis using ICP-MS insert ignore into journalissuearticles values(Inductively Coupled Plasma-Mass Spectrometry); were evaluated statistically by using SPSS program. When cancerous and healthy tissues were compared, Pb amount was significantly higher in cancerous tissues compared to healthy tissues insert ignore into journalissuearticles values(p <0.05);. These results suggest that heavy metals accumulated in the body may be effective in the development of colon cancer.
Keywords : Colon Cancer, FFPE Tissue, ICP MS, Trace Elements