FIXED-DOSE COMBINATION-ORALLY DISINTEGRATING TABLET (FDC-ODT) STUDIES FOR THE TREATMENT OF TYPE 2 DIABETES OR CARDIOVASCULAR DISEASES-A MINI REVIEW

Authors : Meltem ÇETİN

Pages : 70-81

View : 15 | Download : 7

Publication Date : 2022-10-14

Article Type : Review Paper

Abstract :The orally disintegrating tablet insert ignore into journalissuearticles values(ODT); is a dosage form that stands out for its organoleptic elegancy, better patient compliance, rapid disintegration, and rapid onset of action in geriatric, psychiatric, pediatric, paralyzed, and bedridden patients. Drug combination therapy refers to the concomitant use of two or more drugs used separately or the use of two or more active pharmaceutical ingredients insert ignore into journalissuearticles values(APIs); in fixed-dose combinations insert ignore into journalissuearticles values(FDCs); in a single dosage form. FDC drug products have been developed to target a single disease or multiple diseases/conditions. There have been studies showing that taking FDC drug products may be more effective than using dosage forms containing individual APIs. However, the safety, efficacy, and rationality of many FDCs still remain questionable. Furthermore, FDC-ODTs combine the advantages such as better compliance and efficacy of both FDC and ODTs, especially in dysphagic patients and the patients on multiple drug therapy. FDC-ODTs have been prepared for the treatment of different diseases such as Type 2 diabetes, epilepsy, cardiovascular disease, Parkinson’s disease. In this mini-review, I aimed to provide an overview with some studies on FDC-ODTs prepared for cardiovascular diseases and Type 2 diabetes treatments in the literature.
Keywords : Cardiovascular diseases, fixed Dose Combination, orally Disintegrating Tablet, Type 2 diabetes