Square Wave and Differential Pulse Voltammetric Determination of Meloxicam in Pharmaceutical Formulations

Authors : Fatma DEMİRKAYA MİLOĞLU

Pages : 1-10

View : 13 | Download : 9

Publication Date : 2022-01-25

Article Type : Research Paper

Abstract :Two new voltammetric methods insert ignore into journalissuearticles values(square wave insert ignore into journalissuearticles values(SWV); and differential pulse insert ignore into journalissuearticles values(DPV);); were developed and validated for the direct determination of meloxicam insert ignore into journalissuearticles values(MX); in pharmaceutical formulations insert ignore into journalissuearticles values(PFs); without any pre-processes steps. The anodic peaks were obtained in buffer insert ignore into journalissuearticles values(pH 4.85); on glassy carbon electrode insert ignore into journalissuearticles values(GCE);. The both voltammetric methods were linear at concentration range of 10-90 µg/mL in PF. The validation of methods for MX in PF were determined by establishing specificity, linearity, sensitivity, precision, accuracy, recovery and ruggedness. The recovery results of MX in PFs were found as % 98.5 for SWV and % 98.7 for DPV, respectively. The both developed voltammetric methods were successfully applied for the determination of MX in PFs named Melox, Melcam and Zeloxim. The endogenous substances found in PF were not create electroactive interferences for determine MX. The obtained analysis results of the PFs containing MX by voltammetric methods were compared by using the student t-test with the claimed values and no found statistically differences. It is claimed that new voltammetric methods can be used routinely MX analysis in PFs.
Keywords : Differential pulse voltammetry, meloxicam, pharmaceutical, square wave voltammetry