Evaluation Excipients and pH Effects on Impurity of Desloratadine Syrup Formulation

Authors : Osman ÜNAL

Pages : 35-40

View : 29 | Download : 23

Publication Date : 2023-05-27

Article Type : Research Paper

Abstract :The goal of the research work was to compare the excipient and pH effect develop a stabile pharmaceutical product which is Desloratadine syrup. A total of seven formulations were prepared and syrup to stability study. This study is used different excipients and is tried pH for improve product. To improve the stability of Desloratadine formulations insert ignore into journalissuearticles values(F1-F7); were evaluated with different excipients and pH during stability period. Stability studies were performed to evaluate impurity and assay of desloratine. The rate of initial and 6th months impurity results were compared to F1-F7 formulations. As a result of initial, 3rd and 6th months impurity analysis for F7 formulations were found to be within in limit. According to the evaluation results, the F-7 formulation was chosen as the stabilize and best formulation. Those results showed that the F-7 formulation was stable in the stability studies. Both of them were determined to the best formulations about impurity and pH of desloratadine.
Keywords : Drug formulation, Desloratadine, syrup, excipient, pH, stability study, impurity, HPLC