PARTIAL PROTECTIVE EFFECTS OF L. PLANTARUM ADMINISTRATION ON SOME BLOOD PARAMETERS AND ANAE-POSITIVE LYMPHOCYTE RATIOS IN FEMALE RATS EXPOSED TO CADMIUM (Cd)

Authors : İhsan KISADERE, Hakan TAVŞANLI, Mehmet Faruk AYDIN, Özkan DEMİRBAŞ

Pages : 160-170

Doi:10.52538/iduhes.1251431

View : 38 | Download : 41

Publication Date : 2023-05-26

Article Type : Research Paper

Abstract :We aimed to research the influences of oral L.plantarum administration on some blood parameters and alpha-naphthyl acetate esterase insert ignore into journalissuearticles values(ANAE);-positive lymphocyte ratios in female rats exposed chronically to Cd. In order to perform this investigation, rats were separated into four equal groups as control insert ignore into journalissuearticles values(C, n = 8);, cadmium insert ignore into journalissuearticles values(Cd, n = 8);, L.plantarum insert ignore into journalissuearticles values(n = 8);, and Cd+ L.plantarum insert ignore into journalissuearticles values(n = 8);. Cd insert ignore into journalissuearticles values(2.04 mg / mL); was orally applicated to Cd and Cd+ L.plantarum groups for 28 days. In addition, active-live L.plantarum insert ignore into journalissuearticles values(approximately 108 - 109 cfu / mL); was applicated orally to L.plantarum and Cd+ L.plantarum groups at the same time. C group animals received only fresh water and standard rat food during the study. After the applications, animals were decapitated and blood samples were collected for evaluating of some blood parameters insert ignore into journalissuearticles values(WBC and its different sub-types, RBC, HCT, MCV, MCH, MCHC, and PLT); and also ANAE-positive lymphocyte ratios. WBC counts were determined the highest in the Cd group compared to other experimental groups insert ignore into journalissuearticles values(p < 0.05);. On the other hand, LP administration caused a significant amelioration in WBC counts of Cd+ L.plantarum group animals when compared to Cd group insert ignore into journalissuearticles values(p < 0.05);. Although NEU counts were detected the highest in the Cd group, these counts decreased due to oral L.plantarum administration in Cd+ L.plantarum group insert ignore into journalissuearticles values(p < 0.05);. Increased PLT values due to CD administration were fixed by using LP diet in the Cd+ L.plantarum group compared to the Cd group in the study insert ignore into journalissuearticles values(p < 0.05);. In conclusion, L.plantarum partially affects female rats’ blood parameters from the harmful effects of Cd.
Keywords : Lactobacillus plantarum, kadmiyum, dişi rat, hematoloji, ANAE pozitif