Triglyceride-Glucose Index is a novel predictor of colorectal cancer

Authors : Erkan Aksoy, Zeynep Ergenç, Hasan Ergenç, Feyzi Gökosmanoğlu

Pages : 44-49

Doi:10.34084/bshr.1311813

View : 45 | Download : 31

Publication Date : 2024-04-30

Article Type : Research Paper

Abstract :Aim: Colorectal cancer is the leading cause of cancer-related mortality. Metabolic syndrome is associated with obesity, pre-diabetes, and dyslipidemia. The purpose of the study was to investigate the effects of TyG Index as a novel biomarker on CRC risk. Material and Method: The study was conducted with 256 people in total, including the CRC (n=124) and Control Groups (n=132). TyG Index was calculated by using fasting triglycerides and glucose with the formula Ln [fasting TGs (mg/dL) x fasting glucose (mg/dL)/2]. The performance of the TyG Index to predict the presence of CRC was also evaluated. Results: Metabolic parameters associated with insulin resistance were found to be at statistically significant levels in the CRC Group. Fasting plasma glucose, triglyceride, insulin, hemoglobin A1c, and GGT were also statistically significant. It was also determined that the cut-off value of the TyG Index for the presence of CRC was 4.49 (AUC = 0.782, sensitivity 77%, specificity = 78.4%, and p=0.002). Conclusion: In the present study, it was found that the TyG Index is associated with the risk of CRC and can be used as a novel biomarker in high-risk CRC cases.
Keywords : TyG İndeksi, Kolorektal kanser, İnsülin direnci