How do viruses use oxidative stress?

Authors : Ece ADIGÜZEL, Tuba Çiğdem OĞUZOĞLU

Pages : 90-97

Doi:10.30704/http-www-jivs-net.1117825

View : 17 | Download : 9

Publication Date : 2022-08-31

Article Type : Review Paper

Abstract :Oxygen is a vital element for all living beings to continue their life activities and is the main component of oxidant–antioxidant metabolism, which should be in balance. The free radicals formed as a result of this metabolic process in the organism constitute a source of oxidants; external factors insert ignore into journalissuearticles values(radiation, exposure to sunlight, environmental pollution, cigarettes, etc.);, inflammation and microbial agents also cause the formation of oxidants. Oxidative stress occurs when the balance between free radicals and antioxidants insert ignore into journalissuearticles values(which have an eliminating effect against them); shifts in favour of free radicals. Many studies have reported that oxidative stress may affect the virulence of pathogens during infection. Viruses use a pathological pathway that causes the production of reactive oxygen species insert ignore into journalissuearticles values(ROS); and the consumption of antioxidants. Thus, after viral infections, higher levels of ROS are often formed. Not only DNA-containing but also RNA-containing viruses were found to be associated with severe oxidative stress supporting DNA damage, high mutagenicity, initiation and/or progression of neoplasia. This review focuses on the relationship between oxidative stress and viruses.
Keywords : oxidative stress, viruses, virus infections, oxidative stress in infections