A Preventive herb against bone loss in diabetic rats: Zingiber officinale

Authors : Bayram SÜZER, Nilay SEYİDOĞLU, Kenan TÜFEKÇİ, Deniz KARAKCI, Buket BAKIR

Pages : 76-83

Doi:10.30704/http-www-jivs-net.1120974

View : 21 | Download : 12

Publication Date : 2022-08-31

Article Type : Research Paper

Abstract :The study aims to determine and compare bone mechanical and material properties in experimentally diabetic rats treated with ginger extract. Forty female, healthy Wistar albino rats were used in the study. Rats were divided into five groups; Control insert ignore into journalissuearticles values(C);, Sham insert ignore into journalissuearticles values(S);, Ginger insert ignore into journalissuearticles values(G);, Diabetic insert ignore into journalissuearticles values(D);, and Diabetic rats treated with Ginger insert ignore into journalissuearticles values(DG);. Diabetes mellitus was induced by a single intraperitoneal injection of 50 mg/kg streptozotocin. Ginger-treated rats received 200 mg/kg ginger extract by oral gavage in a 30-day-trial. At the end of the study, tibiae were harvested and subjected to a three-point bending test. Plasma samples were also analyzed for calcium and phosphorus concentrations. It was observed that the bending strength significantly decreased in the groups Ginger insert ignore into journalissuearticles values(234.78 ± 16.79; P = 0.019); and the Diabetic insert ignore into journalissuearticles values(223.90 ± 29.90; P = 0.028); compared to group Control insert ignore into journalissuearticles values(275.75 ± 33.47);. In addition, the bending strength of the diabetic rats treated with ginger insert ignore into journalissuearticles values(DG group; 251.92 ± 15.90); was also significantly higher than the rats in the Ginger and Diabetic groups insert ignore into journalissuearticles values(P = 0.032 and P = 0.037, respectively);. Although the plasma calcium concentrations showed no differences among any of the groups, the plasma phosphorus levels decreased significantly in group Diabetic insert ignore into journalissuearticles values(3.47 ± 0.28; P = 0.05); compared to Control insert ignore into journalissuearticles values(5.11 ± 0.21);. However, there was a significant increase in plasma phosphorus in group DG insert ignore into journalissuearticles values(4.32 ± 0.12; P = 0.05); compared to Diabetic. In conclusion, ginger extract treatment of diabetic rats improves bone material properties. The adverse effects of diabetes on the mechanical properties of the bone were prevented by using ginger extract in diabetic rats.
Keywords : Biomechanics, diabetes mellitus, ginger, Zingiber officinale, rats