Determination of Indomethacin-Induced Gastric Ulcer Healing Effects of Several Propolis Extracts and Compared with Omeprazole

Authors : Ali Sorucu, Osman Bulut, Ayşe Nur Akkoç, Gizem Demir

Pages : 24-36

View : 87 | Download : 51

Publication Date : 2025-06-20

Article Type : Research Paper

Abstract :Gastric ulcers are an essential problem for both human and animal health. Several medications are used to treat peptic ulcers. Long-term use of these drugs also causes various complications. For this reason, using natural products to treat ulcers has become very popular in recent years. Propolis is an important bee product used in apitherapy, which has various biological activities due to its many active ingredients. Due to its phenolic compounds, it is effective in preventing ulcer formation and accelerating healing. Varying the propolis content according to the solvent used naturally alters its efficiency. This study aimed to compare with omeprazole and to investigate the efficacy of hydro-alcoholic, water, DMSO, and olive oil propolis extracts in a mouse model of indomethacin-induced gastric ulcer. On histopathological examination, epithelial loss, erosion, bleeding, oedema, and inflammatory cell infiltration were scored separately and concerning the overall clinical score. Olive oil and DMSO extracts of propolis were found to be almost as effective as omeprazole. In contrast, water extract was found to be weak, and hydro-alcoholic extract had no effect, which even worsened some parameters. The results showed that the ulcer healing potential of propolis could be statistically different depending on the solvent. It was also found that DMSO and olive oil extracts of propolis have the potential to heal peptic ulcers.
Keywords : Gastrik ülser, Bal arısı, Apiterapi, DMSO, Zeytinyağı, Propolis

ORIGINAL ARTICLE URL