Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model?

Authors : Esin AVCI, Nazlı ÇİL, Hülya AYBEK, Zafer AYBEK

Pages : 96-103

Doi:10.30621/jbachs.2020.794

View : 24 | Download : 10

Publication Date : 2020-06-01

Article Type : Research Paper

Abstract :Objective: Chronic kidney disease CKD is still common worldwide. We investigated the effect of two different doses of vitamin E with selenium Se administration to prevent CKD leads to renal damage via unilateral ureteral obstruction UUO . Material and Methods: Thirty-two female Wistar Albino rats were divided into four groups; a sham group left UUO+no medication ; left UUO with no treatment, left UUO treated with 100 mg/kg dose Vitamin E+Se RPVE+Se and left UUO treated with 1000 mg/kg Vitamin E+Se HDVE+Se mixture. All rats subjected during 14 days and killed humanely. Malondialdehyde MDA , superoxide dismutase SOD , glutathione GSH , levels were determined in kidney tissue, whereas total antioxidant status TAS , total oxidant status TOS and DNA damage marker 8-hydroxy-2-deoxyguanosine 8-OHdG in serum. Histologic examination were also done. Results: The unilateral ureteral obstruction model increased MDA p
Keywords : Vitamin E supply distribution, renal insufficiency, Selenium supply distribution, ureter