Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017

Authors : Orhan SAHİN, Gamze GÖKALP, Nil HOCAOGLU, Engin YILDIZTEPE, Şule KALKAN

Pages : 156-161

Doi:10.30621/jbachs.855719

View : 21 | Download : 7

Publication Date : 2021-05-27

Article Type : Research Paper

Abstract :Purpose: The purpose of our study is to reveal the demographic features, exposure routes and reasons for exposure, clinical effects and outcomes of cardiovascular drug poisonings reported to the Dokuz Eylul University Drug and Poison Information Center insert ignore into journalissuearticles values(DEUDPIC); between January 2014 and December 2017. Methods: This retrospective, descriptive, and cross-sectional study was approved by the Noninvasive Research Ethics Committee of Dokuz Eylül University School of Medicine. All data were recorded on standard data forms and then transferred to a software insert ignore into journalissuearticles values(Ruber, written by Engin Yildiztepe, 2007); for data analysis. Results: There were 43 poisonings cases were reported with cardiovascular drugs. Female cases were common insert ignore into journalissuearticles values(60.47%);. Half of the poisoning cases were toxic insert ignore into journalissuearticles values(51.16%);. The most common reason of poisonings was intentional insert ignore into journalissuearticles values(81.40%);. All of cases between 13-49 age group were intentional exposures. Only single substance intakes were responsible for the most of the drug exposures insert ignore into journalissuearticles values(62.79%);. The most common agents were beta-blockers insert ignore into journalissuearticles values(29.85%);, medicines that affect the renin-angiotensin system insert ignore into journalissuearticles values(23.88 %);, calcium channel blockers insert ignore into journalissuearticles values(11.94%); and cardiac therapy drugs such as digoxin insert ignore into journalissuearticles values(11.94%);. Clinical signs and symptoms were classified as asymptomatic insert ignore into journalissuearticles values(37.21%);, mild insert ignore into journalissuearticles values(23.26%);, moderate insert ignore into journalissuearticles values(23.26%);, and severe insert ignore into journalissuearticles values(4.65%);. Recommended treatments were observation and supportive care insert ignore into journalissuearticles values(46.67%);, decontamination methods insert ignore into journalissuearticles values(44.00%); and antidote therapy insert ignore into journalissuearticles values(2.67%);. One fatality was reported. Conclusions: We suggest that determination of the epidemiological characteristics of cardiovascular drug exposures in our country through prospectively multi-centered studies may provide significant contributions to prevent poisonings and decrease the mortality and morbidity of the cases.
Keywords : Cardiovascular drugs, Drug and Poison Information Center, Poisoning and Toxicity