Tescalcin over-expression increases Keratin 18 and 19 in K562 cells

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Journal of Basic and Clinical Health Sciences
Volume:6 Issue:3
Tescalcin over-expression increases Keratin 18 and 19 in K562 cells

Tescalcin over-expression increases Keratin 18 and 19 in K562 cells

Authors : Hande EFE, Özge UYSAL YOCA, Umut Özerk ÖNKOL, Zeynep YUCE

Pages : 858-862

Doi:10.30621/jbachs.1101524

View : 19 | Download : 11

Publication Date : 2022-09-29

Article Type : Research Paper

Abstract :Tescalcin insert ignore into journalissuearticles values(TESC); has been shown to be essential in mammalian cells as a regulator of intracellular Ca2+. Ca2+ is a second messenger functioning in many metabolic pathways as well as in cell differentiation, cell size and the cell cycle. K562 cells over-expressing TESC change their morphology and adopt adherent properties. Considering differences in morphology may have been reflected in changes of the cytoskeleton, we focused on the expression levels of keratins, which are cytoskeletal intermediate filaments in epithelial cells and also expressed in K562. We over-expressed the TESC gene via lentiviral transduction and analyzed keratin 8 insert ignore into journalissuearticles values(K8);, keratin 18 insert ignore into journalissuearticles values(K18);, and keratin 19 insert ignore into journalissuearticles values(K19); expression.
Keywords : Keratins, TESC, K562

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