Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience

Authors : Vildan GÜNGÖRER, Ebru YILMAZ KESKİN, Tunç FIŞGIN

Pages : 359-364

Doi:10.16899/jcm.605404

View : 20 | Download : 9

Publication Date : 2019-12-31

Article Type : Research Paper

Abstract :Abstract Aim: Analysis of the data of children following stem cell transplantation. Materials and Methods: A total of 44 children who received stem cell transplant between February 2009 and May 2011 were evaluated retrospectively. Results: Among the patients with a mean age of 9.6 ± 4.63 years, 20 insert ignore into journalissuearticles values(45.5%); were male, whereas 24 insert ignore into journalissuearticles values(54.5%); were female. The initial diagnosis of the patients with decreasing order of frequency was as follows: thalassemia major insert ignore into journalissuearticles values(n=15);, acute leukemia insert ignore into journalissuearticles values(n=9);, Fanconi aplastic anemia insert ignore into journalissuearticles values(n=6);, aplastic anemia insert ignore into journalissuearticles values(n=5); and other disorders insert ignore into journalissuearticles values(n=9);. Disease-free survival in two years was observed in 27 insert ignore into journalissuearticles values(61.3%); of patients. Relapse occurred in 8 insert ignore into journalissuearticles values(18.1%); patients, whereas 9 insert ignore into journalissuearticles values(20.4%); patients died. The mortality was transplant-related in two cases, whereas it was due to progression of the underlying disease in 7 insert ignore into journalissuearticles values(15.9%); patients. Conclusion: As the stem cell transplantation has become widespread in Türkiye recently, its data are valuable. We found high incidence of mucositis and infection due to myeloablative regimens. The limitation of our study is the small number of patients included.  Though, results obtained here are similar to those of national and international studies. 
Keywords : Hematopoietic stem cell transplantation, prognosis, transplant related mortality