Do Alterations In Serum Leptin, Adiponectin, Resistin, C Peptide, Il-10, Il-22 And Visfatin Levels Have An Impact On Survival In Patients With Advanced Stage Gastric And Colon Cancer?

Authors : Can ÖZLÜ, Gamze GOKOZ DOGU, Ayşegül KARGI, Hakan AKÇA, Aydın DEMİRAY, Burcu YAPAR TAŞKÖYLÜ, Atike Gökçen DEMİRAY, Serkan DEĞİRMENCİOĞLU, Arzu YAREN, Ahmet ERGİN

Pages : 451-458

View : 71 | Download : 82

Publication Date : 2023-05-31

Article Type : Research Paper

Abstract :Abstract Background/Aims: Pathogenesis of cancer cachexia is not fully understood yet; however, adipocytokines are considered necessary in this context. In this study, leptin, adiponectin, resistin, c-peptid, IL-10, IL-22, visfatin which are considered to be among markers of cancer cachexia were assessed. Methods: Fifty-three patients insert ignore into journalissuearticles values(34 male, 19 female); and 20 healthy people as a control group were included into this study. Blood samples were stored in deep freeze at -70 ºC and all of the samples were analyzed with appropriate biochemistry kit. Along with demographic data and laboratory tests results serum adiponectin, leptin, IL-10, IL-22, C peptide, resistin, visfatin levels were measured in 3 different time period both in patient and control group. Statistical data were evaluated by SPSS v22. Results: There was no statistically significant relationship between adipocytokine levels and progression-free survival. Higher resistin and IL-10 levels were associated with shorter overall survival insert ignore into journalissuearticles values(p=0.035, p=0.14, respectively);. There was no significant relationship between other cytokines and overall survival. Multivariate analysis has shown that higher serum Ca 19.9 levels insert ignore into journalissuearticles values(OR 0.226, P=0.005);, lower BMI insert ignore into journalissuearticles values(OR 5.726, p= 0.007);, higher serum IL-10 levels insert ignore into journalissuearticles values(OR 0.329, p= 0.042); were factors showing an impact on progression-free survival; lower serum albumin levels insert ignore into journalissuearticles values(OR 0.282, p=0.013);, higher serum LDH levels insert ignore into journalissuearticles values(OR 0,338, p=0.012);, low BMI at diagnosis insert ignore into journalissuearticles values(OR 5.19, P<0.0005); were factors having an impact on overall survival. Conclusions: Our study detected an association between resistin, adipocytokine, and IL10 level and overall survival.
Keywords : Cancer cachexia, Cancer cachexia, Adipocytokines, Adipocytokines, Adiponectin, Gastric cancer, Colon cancer

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