Diagnostic Value of Target Sign and Apparent Diffusion Coefficient Measurements in the Differentiation between Hepatocelular Carcinoma and Liver Metastasis on Diffusion Weighted Magnetic Resonance Imaging

Authors : Eda ALBAYRAK, Özge GÜMÜŞAY, Sadık SERVER

Pages : 473-478

Doi:10.16899/jcm.1268072

View : 56 | Download : 48

Publication Date : 2023-05-31

Article Type : Research Paper

Abstract :Objective: The aim of our study is to investigate probable differences between the incidence of target sign detected by diffusion-weighted magnetic resonance imaging insert ignore into journalissuearticles values(DWI); and apparent diffusion coefficient insert ignore into journalissuearticles values(ADC); values between metastases and hepatocellular carcinomas insert ignore into journalissuearticles values(HCC);. Materials and Methods: A total of 155 lesions obtained from 57 insert ignore into journalissuearticles values(female/male: 18/39); patients were included in the study. Dimensions of lesions, the appearance of lesions detected by DWI, minimum ADC insert ignore into journalissuearticles values(ADCmin); values, and average ADC insert ignore into journalissuearticles values(ADCav); values were evaluated with 1.5 Tesla MRI using b= 0 and b = 1000 s/mm2 values. Differences between metastases and HCC were investigated in terms of defined parameters. Also, ROC insert ignore into journalissuearticles values(receiver operating curve); analysis was used to evaluate the performance of ADCmin and ADCav parameters in distinguishing metastases from HCC. Results: Of the lesions, 131 were metastases, while 24 were HCC. The image showing centrally hypointense, periphery hyperintense signal in DWI defined as target sign. Target sign detected in 72 metastatic lesions insert ignore into journalissuearticles values(55%); and 6 HCC lesions insert ignore into journalissuearticles values(25%); with DWI, and the rate of target sign detection was higher in the metastatic group compared with HCC insert ignore into journalissuearticles values(p<0.007);. Also, ADCmin and ADCav values were found to be higher in the HCC group compared with the metastatic group insert ignore into journalissuearticles values(p<0.001);. Based on ROC analysis optimal ADCmin and ADCav values were <758 x10-6 and <817x10-6 mm2/s, respectively, in distinguishing metastasis from HCC insert ignore into journalissuearticles values(Sensitivity: 0.412, 0.412; Specificity: 0.875, 0.917 respectively);. Conclusion: Target sign detected by DWI and ADC values can be used as MRI markers that enhance diagnostic accuracy in distinguishing between metastases and HCC.
Keywords : Hedef İşareti, Difüzyon Ağırlıklı Manyetik Rezonans Görüntüleme, metastaz, Hepatosellüler karsinom

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