Comparison of the Predictive Role of First Trimester APRI Score and De-Ritis Ratio in Intrahepatic Cholestasis of Pregnancy

Authors : Burcu Dinçgez, Gülten Özgen, Levent Özgen

Pages : 222-227

View : 156 | Download : 131

Publication Date : 2024-09-25

Article Type : Research Paper

Abstract :Aim: The APRI score and De Ritis ratio is associated with liver diseases. There is limited data in the literature on the predictive role of these markers in intrahepatic cholestasis of pregnancy. This study aimed to evaluate and compare the predictive role of first trimester APRI and De Ritis scores for intrahepatic cholestasis of pregnancy. Material and methods: A total of 60 intrahepatic cholestasis of pregnancy and 60 healthy pregnant were included in this retrospective study. Demographic features, first trimester aminotransferases, complete blood count levels, fasting bile acid levels, coagulation tests, birth outcomes were recorded and compared between groups. Receiver operating curve was used to determine the predictive role of APRI and De-Ritis score for intrahepatic cholestasis of pregnancy. Results: APRI score was significantly higher (p=0.017) whereas De-Ritis ratio was lower (p=0.002) in intrahepatic cholestasis group. Fasting bile acid was found to be positively correlated with APRI score (r=0.868, p 0.42 predicted intrahepatic cholestasis with 36.67% sensitivity and 98.33% specificity (AUC=0.626, p=0.016). De Ritis ratio ≤1.3 predicted intrahepatic cholestasis with 83.33% sensitivity and 51.67% specificity (AUC=0.664, p=0.001). No significant difference was found between two index for predicting intrahepatic cholestasis (p=0.065). Conclusion: The first trimester APRI and De Ritis scores, which are cheap and easily available, can be used to predict intrahepatic cholestasis of pregnancy. Considering that there is no superiority between two markers, we suggest that both can be used for prediction.
Keywords : APRI skoru, De Ritis oranı, gebeliğin intrahepatik kolestazı

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