Recurrence of Germ Cell Testicular Tumor Presenting with Choriocarcinoma Syndrome and Acute Pancreatitis

Authors : Handan Özen Olcay, Emine Emektar, Yunsur Çevik

Pages : 53-55

Doi:10.33706/jemcr.1612873

View : 40 | Download : 17

Publication Date : 2025-06-29

Article Type : Other Papers

Abstract :Abstract Introduction: Choriocarcinoma syndrome (CS), characterized by pulmonary hemorrhage, widespread metastases, and markedly elevated beta-human chorionic gonadotropin levels, poses significant challenges in both diagnosis and treatment. Case report: In this case report, we present a rare case of recurrent mixed germ cell testicular tumor presenting to the emergency department with acute respiratory distress syndrome (ARDS) secondary to CS and pancreatitis. Conclusion: CS is a rare but highly fatal syndrome, often arising as a complication of advanced-stage germ cell tumors. Since these patients primarily present to emergency departments, it is crucial for emergency physicians to consider CS in the differential diagnosis when young male patients with a history of testicular tumors present with acute respiratory distress, hemoptysis, abdominal pain, or symptoms resembling pancreatitis. References 1. Nauman M, Leslie SW. Nonseminomatous Testicular Tumors. 2023 Aug 14. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 33760513. 2. Xiao QF, Li J, Tang B, Zhu YQ. Testicular mixed germ cell tumor: A case report. World J Clin Cases. 2023 Oct 6;11(28):6902-6907. doi: 10.12998/wjcc.v11.i28.6902. 3. Rejlekova K, Cursano MC, De Giorgi U, Mego M. Severe Complications in Testicular Germ Cell Tumors: The Choriocarcinoma Syndrome. Front Endocrinol (Lausanne). 2019 Apr 12;10:218. doi: 10.3389/fendo.2019.00218. 4. Zeitjian VS, Arslan W, Borja-Alvarez A, Amar S. Choriocarcinoma Syndrome: A Potentially Fatal Complication of Testicular Cancer. Case Rep Oncol Med. 2019 Feb 24;2019:4092941. doi: 10.1155/2019/4092941. 5. Magudia K, Menias CO, Bhalla S, Katabathina VS, Craig JW, Hammer MM. Unusual Imaging Findings Associated with Germ Cell Tumors. Radiographics. 2019 Jul-Aug;39(4):1019-1035. doi: 10.1148/rg.2019180050. 6. Trpchevska EN, Todorovska B, Todorovska MB, Trajkovska M, Nikolova D, Dzambaz D, et al. Testicular Mixed Germ Cell Tumor Presenting with Upper Gastrointestinal Bleeding: A Case Report. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Jul 15;44(2):47-52. doi: 10.2478/prilozi-2023-0024. 7. Tannous T, Miskovsky J, Keating M. Testicular Germ Cell Tumors: Paraneoplastic Syndromes and the Role of Beta-Human Chorionic Gonadotropin. Cureus. 2021 Apr 4;13(4):e14286. doi: 10.7759/cureus.14286. 8. Soputro NA, Roberts J, Wong S, Dias BH. Pretreatment of choriocarcinoma syndrome: a rare complication of metastatic germ cell tumours. BMJ Case Rep. 2022 Mar 2;15(3):e248172. doi: 10.1136/bcr-2021-248172. PMID: 35236696; PMCID: PMC8895934. 9. Kandori S, Kawai K, Fukuhara Y, Joraku A, Miyanaga N, Shimazui T, et al. A case of metastatic testicular cancer complicated by pulmonary hemorrhage due to choriocarcinoma syndrome. Int J Clin Oncol. 2010 Dec;15(6):611-4. doi: 10.1007/s10147-010-0092-3. 10. Agrawal T, Blau AJ, Chwals WJ, Tischler AS. A Unique Case of Mediastinal Teratoma with Mature Pancreatic Tissue, Nesidioblastosis, and Aberrant Islet Differentiation: a Case Report and Literature Review. Endocr Pathol. 2016 Mar;27(1):21-4. doi: 10.1007/s12022-015-9393-4. 11. Suda K, Mizuguchi K, Hebisawa A, Wakabayashi T, Saito S. Pancreatic tissue in teratoma. Arch Pathol Lab Med. 1984 Oct;108(10):835-7.
Keywords : Koryokarsinom sendromu, Acil servis, Germ hücreli testis tümörleri, Pankreatit.

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