Practıcal Aspects of 68Ga-Labelled Dota-Peptides for Peptide-Receptor Radionuclide Therapy

Authors : Betül TAŞDELEN

Pages : 149-155

Doi:10.30931/jetas.297622

View : 6 | Download : 5

Publication Date : 2016-12-27

Article Type : Research Paper

Abstract :68Gallium-labeled receptor ligands, such as 68Gallium DOTATOC, 68Gallium-DOTANOC, and 68Gallium-DOTATATE which are used in PET are becoming gold standard of 68Ga-labeled peptides. The 68Ga-labeled peptides show a rapid renal clearance and are rapidly accumulated in the tumors insert ignore into journalissuearticles values(80% within 30 minutes);; concentration in tissues without expression of somatostatin receptors is low, providing higher contrast imaging. Here, this paper presents the practical aspects and the results of preparation and radiolabelling DOTA-peptides with TiO2-based commercially available 68Ge/68Ga generator by using fully automated radiopharmaceutical synthesis device. The radiochemical purity insert ignore into journalissuearticles values(RCP); of 68Ga-labeled DOTA-peptides has been investigated using high performance liquid chromatography insert ignore into journalissuearticles values(HPLC); and instant thin layer chromatography insert ignore into journalissuearticles values(ITLC);. The labeling procedure resulted in high radiochemical yield. The system allows the fully automated, efficient and rapid preparation of 68Ga-DOTA-derivatized peptides.
Keywords : 68Ga, DOTANOC, DOTATATE, peptides, PET