Dapsone can be a new treatment option for reducing the detrimental effect of priapism

Authors : Engin KÖLÜKÇÜ, Bekir Süha PARLAKTAŞ, Nihat ULUOCAK, Faik DERESOY, Velid UNSAL, Muzaffer KATAR

Pages : 800-808

Doi:10.32322/jhsm.963439

View : 38 | Download : 15

Publication Date : 2021-09-24

Article Type : Research Paper

Abstract :Aim: This study aims to analyze the effect of dapsone against ischaemia-reperfusion injury on corporal tissue in a model of induced-priapism in rats. Material and Method: A total of 24 rats were randomized into three groups. Group 1 was defined as the control group. Ischaemia-reperfusion injury was evaluated following the priapism model in Group 2. Group 3 had similar procedures to the rats in Group 2. Group 3 additionally had 12.5 mg/kg dapsone administered intraperitoneally 30 minutes after priapism. Results: Biochemical analysis of blood indicated a significant increase in Group 3 in terms of superoxide dismutase insert ignore into journalissuearticles values(SOD);, glutathione peroxidase insert ignore into journalissuearticles values(GSH-Px); activity and total antioxidant status insert ignore into journalissuearticles values(TAS); values compared with Group 2 insert ignore into journalissuearticles values(p:0.002, p:0.029 and p:0.009, respectively);. The highest values of malondialdehyde insert ignore into journalissuearticles values(MDA);, protein carbonyl insert ignore into journalissuearticles values(PC); and total oxidant status insert ignore into journalissuearticles values(TOS); were recorded in Group 2 insert ignore into journalissuearticles values(p<0.001);. Interleukin 1beta insert ignore into journalissuearticles values(IL-1beta);, Interleukin 6 insert ignore into journalissuearticles values(IL-6); and tumor necrosis factor alpha insert ignore into journalissuearticles values(TNF alpha); levels were found to be significantly decreased in Group 3 compared with Group 2 insert ignore into journalissuearticles values(p:0.022, p:0.049 and p<0.001, respectively);. Direct microscopic evaluation determined an improvement in inflammation, edema, desquamation and vasocongestion scores in Group 3 compared to Group 2 insert ignore into journalissuearticles values(p<0.05);. Conclusion: Dapsone has a protective effect on ischaemia-reperfusion injury in corporal tissue.
Keywords : Dapsone, priapism, ischaemia reperfusion injury, treatment