The pathobiological harmony between the local pulmonary/ bone marrow RAS and its management via tissue-RAS modulating agents in COVID-19

Authors : Ece ÜNAL ÇETİN, Yavuz BEYAZIT, Fatma BEYAZIT, Alpaslan TANOĞLU, İbrahim Celaleddin HAZNEDAROĞLU

Pages : 932-937

Doi:10.32322/jhsm.1090521

View : 25 | Download : 18

Publication Date : 2022-05-30

Article Type : Review Paper

Abstract :Coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19); outbreak, caused by severe acute respiratory syndrome coronavirus 2 insert ignore into journalissuearticles values(SARS-CoV-2);, poses an unprecedented threat to public health and healthcare systems. It presents unusual pathophysiological effects mainly characterized by immune-inflammatory response and prothrombotic state causing acute respiratory distress syndrome and multiple organ failure. SARS-CoV-2 enters target cells after binding to the angiotensin-converting enzyme 2 insert ignore into journalissuearticles values(ACE2); receptor and therefore has a direct effect on the renin-angiotensin system insert ignore into journalissuearticles values(RAS);. Apart from affecting numerous organs including lungs, heart, gastrointestinal system, spleen, brain and kidneys, the spike protein of SARS-CoV-2 could attack hematopoietic stem cells and hematopoietic progenitor cells in bone marrow insert ignore into journalissuearticles values(BM); microenvironment together with the precursor and mature blood cells. Within this hematopoietic viral spread context, it is crucial to search the clinicopathological correlations of COVID-19 in order to develop specific potential therapeutics against pleiotropic SARS-CoV-2 actions. Therefore, pharmacological disruption of the pathological cross-talk of local BM RAS and pulmonary RAS via administration of the tissue-RAS modulating agents such as soluble ACE2, angiotensin insert ignore into journalissuearticles values(1-7);, TXA127 and MAS receptor agonists may prevent the clinical progression of the COVID-19 syndrome via reducing the hematopoietic virus propagation and systemic multi-organ spread.
Keywords : COVID 19, SARS CoV 2, ACE2, renin angiotensin system, bone marrow