The impact of SGLT2-inhibitor therapy on platelet function in type 2 Diabetes mellitus

Authors : Pınar AKHANLI, Sema HEPŞEN, Muhammed KİZİLGUL, Sevgi BİLEN AYHAN, Hakan DÜĞER, Hayri BOSTAN, Muhammed Erkam SENCAR, Bekir UCAN, Erman ÇAKAL

Pages : 140-144

Doi:10.32322/jhsm.1202548

View : 75 | Download : 16

Publication Date : 2023-01-12

Article Type : Research Paper

Abstract :Aim: We consider mean platelet volume insert ignore into journalissuearticles values(MPV);, a pointer of platelet activity related to type 2 diabetes mellitus insert ignore into journalissuearticles values(T2DM); and vascular complications, may have a role in patients using Sodium-Glucose Co-Transporter 2 inhibitors insert ignore into journalissuearticles values(SGLT2i);. Therefore, we aimed to evaluate the MPV change after SGLT2i use in diabetic patients. Matherial and Method: Hemogram parameters such as hemoglobin, hematocrit, and MPV in the 0th and 24th weeks of 102 patients with T2DM that received SGLT2i treatment added to their existing medications and of the control group in which participants are compatible in terms of age and gender factor were compared. Results: A significant increase was observed in the values of MPV and hemoglobin in the 0th and 24th weeks insert ignore into journalissuearticles values(9.3 insert ignore into journalissuearticles values(8.2-10.3); to 10.1±1.3, p<0.001, 13.9±1.42 to 14.4±1.5 p<0.001, respectively);. Similarly, the hematocrit value increased insert ignore into journalissuearticles values(42±3.7 to 44.2±3.8, p<0.001);. There was also a significant increase in both red blood cell insert ignore into journalissuearticles values(RBC); and platelet counts insert ignore into journalissuearticles values(5±0.42 to 5.2±0.47, p<0.001, 252,000 insert ignore into journalissuearticles values(209,000-304,000); to 262,000 insert ignore into journalissuearticles values(221,000-322,000);, p=0.007, respectively);. No correlation was identified in patients with T2DM between MPV and age and gender factors, diabetes duration, body mass index insert ignore into journalissuearticles values(BMI);, fasting and postprandial blood glucose, and insulin use. Conclusion: Contrary to the studies analyzing the relation between MPV and T2DM and its complications, we detected that a 24-week SGLT2i treatment led to an increase in MPV value.
Keywords : SGLT2 inhibitors, mean platelet volume, hematocrit

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