Prognostic role of primary tumor metabolic-volumetric parameters of 18F-fluorodeoxyglucose positron emission tomography in tongue squamous cell carcinoma

Authors : Uğuray AYDOS, Süleyman CEBECİ

Pages : 183-189

Doi:10.32322/jhsm.1220117

View : 45 | Download : 13

Publication Date : 2023-01-12

Article Type : Research Paper

Abstract :Aim: It was aimed to evaluate the prognostic role of primary tumor metabolic-volumetric parameters of 18F-Fluorodeoxyglucose insert ignore into journalissuearticles values(18F-FDG); positron emission tomography/computed tomography insert ignore into journalissuearticles values(PET/CT); in resectable tongue squamous cell carcinoma insert ignore into journalissuearticles values(TSCC);. Material and Method: The imaging findings of 44 TSCC patients insert ignore into journalissuearticles values(23 females, 21 males, mean age: 58±12 years); with resectable tumors who underwent 18F-FDG PET/CT imaging for primary staging before surgery between 2010-2021 were evaluated retrospectively. Maximum standardized uptake value insert ignore into journalissuearticles values(SUVmax);, total lesion glycolysis insert ignore into journalissuearticles values(TLG);, metabolic tumor volume insert ignore into journalissuearticles values(MTV); of primary tumors were acquired from PET/CT. Histopathological risk factors insert ignore into journalissuearticles values(pathological tumor and nodal stage, perineural and lymphovascular invasion, depth of invasion, surgical margin positivity); obtained from surgical resection material of primary tumors were also recorded. The prognostic values of imaging and histopathological parameters were assessed by Cox proportional hazards regression models. Survival curves were estimated by using the Kaplan-Meier analysis. Results: The median follow-up period after diagnosis was 24 months insert ignore into journalissuearticles values(range: 2-152 months);. The univariate and multivariate regression analyses demonstrated that MTV was the only parameter which was significantly related to prognosis for PFS and OS. The patients with higher MTV insert ignore into journalissuearticles values(> 3.13 cm3); had lower PFS and OS rates compared to those with lower MTV insert ignore into journalissuearticles values(≤ 3.13 cm3); insert ignore into journalissuearticles values(p<0.001, p=0.002, respectively);. Conclusion: Primary tumor MTV is an independent prognostic factor in resectable TSCC. PET volumetric features can be used as prognostic biomarker to predict patients with poor prognosis.
Keywords : FDG, Metabolic tumor volume, PET CT, Survival, Tongue squamous cell carcinoma, FDG, metabolic tumor volume, PET CT, survival, tongue squamous cell carcinoma

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