A biomarker predicting unfavorable prognosis in malignant pleural mesothelioma: systemic immune–inflammation index

Authors : Hüsnü BAYKAL, Filiz ÇİMEN

Pages : 389-393

Doi:10.32322/jhsm.1242687

View : 20 | Download : 11

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: Malignant pleural mesothelioma insert ignore into journalissuearticles values(MPM); is an extremely mortal condition. Only a few prognostic biomarkers have been described for MPM. Our study looked into the association between patient survival and the Systemic Immune Inflammation Index insert ignore into journalissuearticles values(SII);. Material and Method: A total of 158 patients who were admitted to our hospital between January 2013 and December 2022, and had a histopathologically confirmed diagnosis of MPM were included in the study. Before treatment, hematological parameters and SII were determined. A Spearman\`s correlation analysis was performed to analyze the correlation of mean survival with hematological parameters. Results: The study involved 158 patients in all. 70 patients had a history of smoking, the median age was 63 years, the mean survival time was 15.3 months, and 57.6% of the participants were men. The epithelioid type insert ignore into journalissuearticles values(84.2%); was the most prevalent histological subtype, and 29 patients had stage 4 illnesses. Of the participants, 84% had received chemotherapy, and 22% had received radiotherapy before. Among the 39 patients who had surgery, 5 had an extrapleural pneumonectomy. SII mean±sd was insert ignore into journalissuearticles values(1427.2±1207.3);. The patients with stage 4 disease had significantly shorter survival insert ignore into journalissuearticles values(p=0.001);. The patients who had surgery survived significantly longer insert ignore into journalissuearticles values(p=0.01);. Hemoglobin insert ignore into journalissuearticles values(Hb); insert ignore into journalissuearticles values(r:0.21, p:0.01); and Hematocrit insert ignore into journalissuearticles values(Hct); insert ignore into journalissuearticles values(r:0.18, p:0.03); values showed weak positive correlations with mean survival. It was evident that mean survival got shorter as SII insert ignore into journalissuearticles values(r:-0.17, p:0.04); and neutrophil-lymphocyte ratio insert ignore into journalissuearticles values(NLR); insert ignore into journalissuearticles values(r:-0.19, p:0.02); values got higher. On the other hand, there was a strong positive association between mean survival and the lymphocyte-monocyte ratio insert ignore into journalissuearticles values(LMR); insert ignore into journalissuearticles values(r:0.21, p:0.01);. When the parameters that had statistically significant differences among the groups were taken as control variables and the statistical analysis was re-performed, it was found that Hgb and Hct values as well as NLR and LMR ratios lost their significant correlations with survival. However, the SII ratio was still negatively correlated with survival insert ignore into journalissuearticles values(r:-0.16, p:0.04);. Conclusion: Pretreatment SII is a noninvasive and easy-to-calculate biomarker that predicts the prognosis of MPM. It is negatively correlated with mean survival regardless of the tumor stage and surgical management.
Keywords : Malignant pleural mesothelioma, systemic immune inflammation index, prognosis, survival