The effect of COVID-19 vaccines on thyroid function and thyroid autoimmunity

Authors : Işılay TAŞKALDIRAN, Feride Pınar ALTAY, Yusuf BOZKUŞ, Özlem TURHAN İYİDİR, Asli NAR, Nilüfer BAYRAKTAR, Neslihan BAŞÇIL TÜTÜNCÜ

Pages : 948-953

View : 43 | Download : 41

Publication Date : 2023-09-28

Article Type : Research Paper

Abstract :Aims: There have been reports about various thyroid autoimmune events after SARS-CoV-2 vaccinations. There is limited data on the extent to which vaccines for COVID-19 are effective on thyroid autoimmunity. This study investigates how COVID-19 vaccination affects thyroid antibodies and functions in individuals without any thyroid disease history. Methods: The study evaluated individuals aged 18-65 with no previous COVID-19 history or thyroid disease who had at least two COVID-19 vaccine doses insert ignore into journalissuearticles values(CoronaVac + Pfizer-BioNTech or Pfizer-BioNTech alone); between October 2021 and October 2022. All participants\` thyroid hormone insert ignore into journalissuearticles values(free triiodothyronine, thyroid-stimulating hormone, and free thyroxine); and thyroid autoantibody insert ignore into journalissuearticles values(anti-thyroglobulin, antithyroid peroxidase, and TSH receptor antibody); levels were measured. Results: The study included 92 individuals in total. Thyroid functions and antithyroid antibody levels were found to be in the normal range before the implementation of the SARS-CoV-2 vaccine. Of the study participants, 42 received the Sinovac + BioNTech vaccine, and 50 received the BioNTech vaccine alone. While a decrease in st4 value was observed only in the BioNTech group after vaccination insert ignore into journalissuearticles values(p=0.007);, thyroid dysfunction was not observed in any participant. After vaccination, TRAB positivity was observed in one participant, ANTI-TPO positivity in six participants, and ANTI-TG positivity in eight participants. No statistically significant antibody positivity was detected. No participants with antibody positivity displayed thyroid dysfunction. Conclusion: Although some positivity in terms of antithyroid antibodies was observed after COVID-19 vaccination, this antibody positivity did not have a statistically significant level, and thyroid dysfunction was not detected in any participant. The COVID-19 vaccine is safe for thyroid function and autoimmunity.
Keywords : COVID 19, Sinovac, BioNTech, anti thyroid peroxidase, anti thyroglobulin, TSH receptor antibody