Is there an association between the serum zonulin concentration and the occurrence of PPROM?

Authors : Şule Atalay Mert, Gizem Aktemur, Tuğba Kınay, Hüseyin Levent Keskin

Pages : 47-51

Doi:10.32322/jhsm.1550594

View : 27 | Download : 71

Publication Date : 2025-01-12

Article Type : Research Paper

Abstract :Aims: The aim is to evaluate the association between intestinal permeability, as assessed by zonulin levels, and preterm premature rupture of membranes (PPROM). Methods: A prospective case-control study was conducted involving 44 pregnant women: 22 with PPROM and 22 matched controls. High-risk pregnancies (gestational diabetes, preeclampsia, multiple pregnancies), chronic diseases, and smoking were exclusion criteria. Demographic and clinical data were collected from medical records. Venous and umbilical cord blood samples were obtained post-delivery, centrifuged at 3000 rpm for 10 min, and stored at -80°C. Results: No significant differences were found between the PPROM and control groups regarding age, body-mass index, gravidity, previous abortions, history of preterm rupture of membrane (PROM), or PPROM. Maternal and cord blood zonulin levels were comparable between groups (p>0.05). In the PPROM group, maternal and fetal cord zonulin levels correlated positively with newborn birthweight (r=0.607, p=0.003; r=0.617, p=0.002, respectively). A strong positive correlation was observed between maternal serum and fetal cord blood zonulin levels (r=0.837, p<0.001). Conclusion: A positive correlation existed between newborn birthweight and both maternal and fetal cord zonulin levels in the PPROM group. Additionally, a strong positive correlation was observed between maternal serum and fetal cord blood zonulin levels in all participants.
Keywords : Zonulin, bağırsak geçirgenliği, PPROM, prematüre preterm membran rüptürü, maternal serum, göbek kordonu kanı