Impact of fetal sex combinations on maternal, pregnancy, and neonatal outcomes in dichorionic twin pregnancies

Authors : Nazan Vanlı Tonyalı, Gülşan Karabay, Betül Tokgöz Çakır, Gizem Aktemur, Zeynep Şeyhanlı, Sevinç Çetin, Nazlı İncekara, Ali Turhan Çağlar

Pages : 313-318

Doi:10.32322/jhsm.1628682

View : 26 | Download : 36

Publication Date : 2025-03-21

Article Type : Research Paper

Abstract :Aims: The aim of this study was to investigate the impact of concordance and discordance in fetal sex on maternal, pregnancy, and neonatal outcomes in dichorionic twin pregnancies. Methods: This retrospective cohort analysis includes DCDA twin pregnancies delivered at Ankara Etlik City Hospital from January 2023 to December 2024. Pregnancies were categorized into three distinct groups according to the combinations of fetal gender: male-male (group 1), female-female (group 2), and male-female (group 3). Maternal demographic, pregnancy, and neonatal outcome data were compared. Composite adverse perinatal outcome (CAPO) was defined as severe neonatal complications. Chi-square, one-way ANOVA, Kruskal-Wallis, and post-hoc analyses were applied with confounder adjustment. Results: Male-male pregnancies were also characterized by significantly increased maternal age, BMI, parity, and diabetic disease rates compared with female-female pregnancies (p 0.05). CAPO rates did not vary between groups significantly (p=0.396). Conclusion: Fetal sex combinations impact neonatal and maternal outcomes of dichorionic twin gestations in varying patterns that differ in male-male versus male-female pregnancies. Greater multicenter numbers are necessary to validate the observations and investigate more fully their consequences for maximally optimizing antenatal treatment and further enhancing perinatal outcome for twin pregnancy.
Keywords : Fetal cinsiyet kombinasyonları, dikoryonik ikiz gebelikler, anne ve yenidoğan sonuçları