The impact of monocyte to HDL ratio and Prognostic Nutritional Index on survival in stage III colorectal cancer patients

Authors : Mehmet Salim Demir, Merve Yumak

Pages : 805-810

Doi:10.32322/jhsm.1740940

View : 123 | Download : 111

Publication Date : 2025-09-16

Article Type : Research Paper

Abstract :Aims: This study explores how systemic inflammatory and nutritional indicators, specifically the monocyte-to-high-density lipoprotein ratio (MHR) and Prognostic Nutritional Index (PNI), influence clinical outcomes in stage III colorectal cancer (CRC) patients. Methods: A retrospective review of 109 individuals was conducted. ROC curve analysis was employed to determine the optimal cut-off values of MHR and PNI for predicting mortality. Survival outcomes, including overall survival (OS) and disease-free survival (DFS), were evaluated using Kaplan-Meier estimates and compared with log-rank tests. Cox regression was utilized to pinpoint factors independently associated with DFS. Results: The findings revealed significantly lower OS among patients not undergoing adjuvant chemotherapy (45.6 vs. 82.2 months; p=0.002). Additionally, diminished MHR (<0.37) and PNI (<46.8) levels were linked to poorer OS (p=0.041 and p=0.003, respectively). While low PNI was also associated with reduced DFS (p=0.021), MHR did not significantly impact DFS (p=0.42). Both MHR (AUC: 0.643) and PNI (AUC: 0.657) demonstrated moderate predictive capabilities for mortality. Importantly, perineural invasion surfaced as an independent negative prognostic factor for DFS (HR: 2.36; p=0.038). Conclusion: In conclusion, pre-treatment MHR and PNI values serve as accessible and low-cost indicators that may assist in prognostic stratification in stage III CRC management.
Keywords : Monosit-HDL oranı, Prognostik Beslenme İndeksi, kolorektal kanser, evre III, sağkalım, prognostik belirteçler

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