Current trends and possible therapeutic options against COVID-19

Authors : Uzair AHMED, Usman Ali ASHFAQ, Saba KHALİQ, Muhammad QASİM, Shah JAHAN, Muhammad Shareef MASOUD

Pages : 110-120

Doi:10.5799/jmid.790198

View : 54 | Download : 10

Publication Date : 2020-09-15

Article Type : Review Paper

Abstract :COVID-19 is a highly contagious disease, caused by SARS-CoV-2, which can be transmitted from person to person. SARS-CoV-2 has thought to be originated in bats and transmitted to humans. SARS-CoV-2 has ssRNA genome that is about 30kb in length and it enters lung epithelial cells using spikes insert ignore into journalissuearticles values(S); by binding with Angiotensin‐converting enzyme 2 insert ignore into journalissuearticles values(ACE-2);. Till date, there is no definitive treatment available for COVID-19 and currently, only symptomatic treatments are available. There is no vaccine developed to combat COVID-19 but scientists are working on developing different types of vaccines including nucleic acid vaccines, subunit vaccines and whole virus vaccines, that are effective and safe to use. Broad spectrum antivirals like ribavirin, lopinavir, ritonavir, arbidol, favipiravir, remdesivir are being test to lessen the viral load. Recently, ivermectin insert ignore into journalissuearticles values(anti-parasitic drug);, has been administered in vitro and showed 99.8% reduction in SARS-CoV-2 in cultured cells in 48 hours. Convalescent plasma insert ignore into journalissuearticles values(CP); treatments are also being used in order to treat critical cases, nevertheless, no drug has been approved yet. This review focuses on the transmission, clinical features, prevention, current treatments and future possible approaches that can be used to develop therapeutic options against COVID-19. J Microbiol Infect Dis 2019; 9insert ignore into journalissuearticles values(3);:110-120.
Keywords : SARS CoV 2, clinical features, therapeutic options, antivirals, vaccines

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