Microbial Etiology of Community Acquired Meningoencephalitis In Adults: A Retrospective Review

Authors : Rohit VASHİSHT, Ram GOPALAKRİSHNAN, Senthur NAMBİ, Dorairajan SURESHKUMAR, Nandini SETHURAMAN, Yamunadevi RAMANATHAN, Ramasubramanian VENKATASUBRAMANİAN

Pages : 15-20

Doi:10.5799/jmid.897133

View : 40 | Download : 4

Publication Date : 2021-03-15

Article Type : Research Paper

Abstract :Objectives: Meningoencephalitis insert ignore into journalissuearticles values(ME); is a well-recognized clinical entity with diverse infectious etiologies. Only a few studies in the Indian literature are available on this issue, especially in the adult population. The aim is to study the microbial etiology of ME presenting to a tertiary care center. Methods: A total of 97 cases labeled as ME were initially found on review of hospital records in a retrospective review over 5 years. Of these, only 62 were microbiologically confirmed and these were selected for this study. Results: Bacteria were the cause in 21insert ignore into journalissuearticles values(34%); cases. Pneumococcus was the predominant bacterial etiology, found in 17 cases insert ignore into journalissuearticles values(detected by PCR in 15 and by culture in 3 cases);. Viruses were seen in 13 insert ignore into journalissuearticles values(21%); cases; Herpes simplex virus insert ignore into journalissuearticles values(HSV); was seen in 4 cases and enterovirus and varicella in 2 cases each insert ignore into journalissuearticles values(all were detected by PCR);. We also had Arboviruses: Chikungunya insert ignore into journalissuearticles values(3 cases); and Dengue insert ignore into journalissuearticles values(2 cases); insert ignore into journalissuearticles values(serological diagnosis);. TB was found in 15 insert ignore into journalissuearticles values(24%); cases insert ignore into journalissuearticles values(diagnosed by positive CSF Xpert Mtb in 11 cases and by AFB culture in 7 cases);. Cryptococcus was seen in another 13 insert ignore into journalissuearticles values(21%); cases insert ignore into journalissuearticles values(detected by positive CSF CRAG in all cases and culture positivity in 7 cases);. Conclusion: Pneumococcus and HSV are the commonest agents causing acute ME syndrome. Mycobacterium tuberculosis and Cryptococcus accounted for all cases of chronic ME. Multiplex PCR insert ignore into journalissuearticles values(in acute ME); and Xpert Mtb and cryptococcal antigen insert ignore into journalissuearticles values(in chronic ME); play an important role in the diagnosis of culture-negative ME. J Microbiol Infect Dis 2021; 11insert ignore into journalissuearticles values(1);:15-20.
Keywords : Meningoencephalitis, etiology, CSF, Xpert Mtb, culture

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