Disseminated Fusariosis with Secondary Hemophagocytic Lymphohistiocytosis

Authors : Garima NİRMAL, Guruprasad Chellappan SOJAMANİ, Manjusha NAİR, Swapna R NATH, Priyakumari THANKAMONY

Pages : 69-73

Doi:10.5799/jmid.1130139

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Publication Date : 2022-06-15

Article Type : Other Papers

Abstract :We report here a 7-year girl with B-Acute Lymphoblastic Leukemia insert ignore into journalissuearticles values(ALL); on Berlin Frankfurt Munster insert ignore into journalissuearticles values(BFM); based induction chemotherapy who presented with fever, cough, and painful necrotic skin lesions simulating pseudomonas sepsis. The patient was eventually diagnosed with disseminated fusariosis. While on combination antifungal therapy, fever reappeared with pancytopenia and hepatosplenomegaly, and she was subsequently diagnosed with secondary Hemophagocytic lymphohistiocytosis insert ignore into journalissuearticles values(HLH); and was treated using the HLH 2004 protocol. The child responded to treatment well. This report highlights the high index of clinical suspicion, appropriate investigations needed to diagnose fusariosis and secondary HLH in pediatric oncology practice promptly, and the successful treatment outcome despite having them both.
Keywords : ALL, Fusariosis, Hemophagocytic Lymphohistiocytosis