The role of vagal-neuroimmunomodulation index in patients with pulmonary arterial hypertension

Authors : Süleyman KALAYCI, Ekrem ŞAHAN, Omaç TÜFEKÇİOĞLU

Pages : 94-97

Doi:10.47582/jompac.1231681

View : 22 | Download : 14

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: The vagal neuroimmunomodulation insert ignore into journalissuearticles values(NIM); index is reflective of the cholinergic inflammatory tone in many clinical circumstances as well as in healthy individuals. We aimed to investigate the relationship of NIM-index on the clinical course patients with PAH. Material and Method: A total of 31 patients diagnosed with pulmonary arterial hypertension insert ignore into journalissuearticles values(PAH); were included in this study. Data on electrocardiography insert ignore into journalissuearticles values(ECG); and C-reactive protein insert ignore into journalissuearticles values(CRP); were retrospectively obtained from patients’ electronic files retrospectively. The vagal NIM index was calculated as heart rate variability insert ignore into journalissuearticles values(HRV); to CRP ratio insert ignore into journalissuearticles values(HRV/CRP);. Results: During clinical follow-up, most patients required hospitalization at least once insert ignore into journalissuearticles values(21 vs. 10 patients);. Consistent with the current literature and as expected, there was a significant difference between the groups in BNP values insert ignore into journalissuearticles values(394 ng/L vs 55 ng/L, p=0.005);. HRV, CRP, and NIM-index values were not found to be significant between the groups. Conclusion: NIM-index values were not associated with the need for hospitalization in patients with PAH.
Keywords : kalp hızı değişkenliği, pulmoner arteriyel hipertansiyon, C reaktif protein CRP, nöroimmünomodülasyon