Effects of hematological parameters on long term mortality in acute ischemic stroke patients

Authors : Nazmi Yaman, Kamil Doğan, Özlem Güler, Buket Tuğan Yıldız
Pages : 277-283
Doi:10.47582/jompac.1544863
View : 63 | Download : 62
Publication Date : 2024-10-26
Article Type : Research Paper
Abstract :Aims: Mortality can be seen in acute ischemic stroke (AIS) in the early or late period. We investigated the role of mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and stroke volume in late-term mortality. Methods: This retrospective cross-sectional study included 132 AIS patients who applied to the emergency department of a university hospital over a consecutive 12-month period. Some patients were excluded from the study according to the exclusion criteria. Patients were divided into groups as survivors and deceased. MPV, NLR, PLR levels in each group were evaluated according to the National Institutes of Health Stroke Scale (NIHSS) scores. Diffusion-weighted MR images (DWI MRs) were evaluated and the infarct volumes of the patients were calculated. Results: The data of a total of 83 AIS patients who remained after exclusion were analyzed. The mean age, NIHSS score and infarct volume of the deceased were statistically significantly higher than the survivors (p<0.01, p=0.026, p=0.021, respectively). According to Spearman’s analysis, NLR, MPV and PLR were negatively correlated with Glasgow Coma Scale (GCS) at presentation, while they were positively correlated with NIHSS and infarct volume. In ROC curve analysis, the optimal cut-off values of NLR, MPV and PLR as predictors of long-term mortality were determined as 4.68, 7.20 and 167.66, respectively. At this level, their sensitivities were 54.84, 48.39, 61.29, respectively, their specificities were 75, 73.08, 73.8, respectively, their positive predictive values were 56.7, 51.7, 57.6, respectively, and their negative predictive values were 73.6, 70.4, 76, respectively, (AUC: 0.64[0.52-0.74 95% CI], 0.64[0.52-0.74 95% CI], 0.66[0.55-0.76 95% CI]). Conclusion: The results showed that MPV, PLR, infarct volume and mean age were independentpredictors of 3-year all-cause mortality in AIS patients.
Keywords : İskemik inme, platelet lenfosit oranı, mortalite, mean platelet volüm, nötrofil lenfosit oranı

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