Measurement of mean platelet volume in the diagnosis of acute ischemic stroke and transient ischemic attack

Authors : Erkan Boğa

Pages : 7-12

Doi:10.47582/jompac.1590302

View : 64 | Download : 58

Publication Date : 2025-02-14

Article Type : Research Paper

Abstract :Abstract Aims: The primary aim of this study is to investigate the potential role of mean platelet volume (MPV) in the diagnostic and prognostic evaluation of acute ischemic stroke (AIS) and transient ischemic attack (TIA), focusing on its clinical significance and role in diagnostic processes. This study aims to evaluate the clinical significance of MPV in patients with AIS and TIA and its role in diagnostic processes. Methods: This retrospective study was conducted between June 15 and December 15, 2014, at the Emergency Medicine Department of Haydarpaşa Numune Training and Research Hospital. The study included 300 patients diagnosed with AIS or TIA and 100 healthy individuals matched for demographic characteristics as the control group. Participants were evaluated based on vascular risk factors such as hypertension, diabetes, and hyperlipidemia, and AIS subgroups were analyzed according to the TOAST classification. MPV and platelet counts, along with biochemical parameters, were measured, and statistical analyses were performed utilizing SPSS software. Results: MPV values in the case group were significantly higher compared to the control group (p<0.001). No significant differences were observed in platelet counts between the two groups (p>0.05). MPV demonstrated no significant associations with hypertension, hyperlipidemia, or other vascular risk factors; however, patients with a history of TIA exhibited higher MPV levels compared to those without, although the difference was not statistically significant. A weak but statistically significant negative correlation was identified between MPV and platelet counts (r=-0.20, p<0.05). Conclusion: MPV demonstrates potential as a significant biomarker in the diagnostic and prognostic processes of AIS and TIA. Nevertheless, the inconsistencies observed in the literature regarding the relationship between MPV and risk factors necessitate more extensive, prospective, and standardized studies to elucidate its clinical utility. The evidence suggests that MPV may contribute to enhancing diagnostic accuracy in clinical practice.
Keywords : Anahtar Kelimeler: Akut iskemik inme, geçici iskemik atak, ortalama trombosit hacmi, biyobelirteç, serebrovasküler hastalık.

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