Echocardiographic evaluation of subclinical ventricular dysfunction in polycystic ovary syndrome: the role of isovolumic acceleration and myocardial performance index

Dogac Oksen; Muzaffer Aslan; Yunus Emre Yavuz; Necip Nas

doi:10.47582/jompac.1600112

Echocardiographic evaluation of subclinical ventricular dysfunction in polycystic ovary syndrome: the role of isovolumic acceleration and myocardial performance index

Authors : Dogac Oksen, Muzaffer Aslan, Yunus Emre Yavuz, Necip Nas

Pages : 27-32

Doi:10.47582/jompac.1600112

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Publication Date : 2025-02-14

Article Type : Research Paper

Abstract :Aims: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with increased cardiovascular risk and potential subclinical ventricular dysfunction. Isovolumic acceleration (IVA) is a novel echocardiographic parameter sensitive to myocardial contractility and less influenced by preload and afterload, making it a promising tool for early detection of cardiac dysfunction. This study aimed to assess the utility of IVA and other echocardiographic markers in identifying subclinical ventricular dysfunction in PCOS patients. Methods: This cross-sectional study analyzed echocardiographic parameters of 59 PCOS patients and 60 age-and BMI-matched controls. Echocardiographic measurements included IVA, myocardial performance index (MPI), and additional indices of right and left ventricular function. Results: PCOS patients exhibited significantly higher BMI and fasting glucose levels (p<0.001) than controls. Left ventricular MPI was elevated in the PCOS group (0.56±0.11 vs. 0.46±0.07, p=0.004). Right ventricular IVA was significantly lower in PCOS patients (2.77±0.69 vs. 3.98±1.01, p=0.030), while tricuspid acceleration time was prolonged (p<0.001). A positive correlation between IVA and MPI was observed in the PCOS group (R=0.453, p<0.001). Multivariate analysis identified PCOS as an independent predictor of subclinical left ventricular dysfunction (OR=0.211, p<0.001). Conclusion: PCOS is associated with subtle alterations in cardiac function, particularly affecting right ventricular systolic function as detected by IVA. These findings highlight IVA\\\'s potential as a non-invasive marker for early cardiovascular risk assessment in PCOS patients, emphasizing the importance of regular cardiac monitoring in this population.
Keywords : Polikistik Over Sendromu, Doku kaynaklı doppler, İzovolümik Hızlanma, Miyokardiyal Performans İndeksi, Subklinik Ventriküler Disfonksiyon

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