Anticancer Activity of Papaver Somniferum

Authors : Döne Aslı GÜLER, Ali AYDIN, Mesut KOYUNCU, İskender PARMAKSIZ

Pages : 349-366

Doi:10.18596/jotcsa.43273

View : 21 | Download : 6

Publication Date : 2017-01-08

Article Type : Research Paper

Abstract :This work describes the pharmacological activity of extracts of Papaver somniferum , a poppy species. P. somniferum products are still considered as a unique source of drug for many diseases. The present study was designed to determine antiproliferative and cytotoxic effects of P. somniferum extracts on HeLa insert ignore into journalissuearticles values(Human Cervix Carcinoma);, HT29 insert ignore into journalissuearticles values(Human Colorectal Adenocarcinoma);, C6 insert ignore into journalissuearticles values(Rat Brain Tumor Cells);, and Vero insert ignore into journalissuearticles values(African Green Monkey Kidney); cell lines. Alkaloids-rich extracts of P. somniferum exhibited antiproliferative effects on various cancer cell lines, especially at high concentrations. We assessed the ability of extracts of P. somniferum to harm the membrane of the cells. Results indicated that P. somniferum extracts destroy cellular membrane in tumor cell lines at high concentrations. Remarkably, the LDH test results disclosed that cytotoxicity of P. somniferum on cells was low at mid concentrations. This may indicate its cytostatic potential. The results of this study support the efficacy of P. somniferum extracts as an anticancer agent.   
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