SYNTHESIS OF NOVEL FLUOROQUINOLONE-TRIAZOLE HYBRID COMPOUNDS AS ANTIMICROBIAL AGENTS

Authors : Serap BAŞOĞLU ÖZDEMİR

Pages : 515-534

Doi:10.18596/jotcsa.55734

View : 10 | Download : 10

Publication Date : 2017-01-08

Article Type : Research Paper

Abstract :Abstract: The hydrazide compound insert ignore into journalissuearticles values( 2 ); was synthesized starting from 1-insert ignore into journalissuearticles values(2-fluorophenyl);piperazine via two stage. The reaction of compound insert ignore into journalissuearticles values( 2 ); with different alkylinsert ignore into journalissuearticles values(aryl);isothiocyanates afforded the corresponding compounds insert ignore into journalissuearticles values( 3a-c ); . 1,3-Thiazolidine derivatives insert ignore into journalissuearticles values( 4a-c ); were synthesized from the treatment of insert ignore into journalissuearticles values( 3a-c ); with ethyl bromoacetate. Mannich bases insert ignore into journalissuearticles values( 6a-d ); were yielded the treayment of insert ignore into journalissuearticles values( 5a-c); with various suitable amines in the exictence of formaldehyde. Compound insert ignore into journalissuearticles values( 3 ); derivatives were converted to 1,2,4-triazole as the starting material of fluoroquinolone analogues insert ignore into journalissuearticles values( 11a-c );. Finally synthesized compounds were examined their biological properties and some of these showed potent activity.
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