SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NEW 1,2,4- TRIAZOLES, MANNICH BASES, CONAZOLES, AND FLUOROQUINOLONES

Authors : Şule CEYLAN

Pages : 747-764

Doi:10.18596/jotcsa.83452

View : 18 | Download : 10

Publication Date : 2017-01-08

Article Type : Editorial

Abstract :Triazoles are heterocyclic compounds which have been of interest in the development of novel compounds with antidepressant, anti-inflammatory, analgesic, antibacterial, antimycobacterial, antifungal, antiviral, anticancer, and other activities. In this article, a series of fluorine- and piperazine-containing some novel biologically active 1,2,4-triazole-3-one derivatives were synthesized by the Mannich reaction of triazole intermediates. The structures for novel synthesized compounds were elucidated using elemental analysis and FT IR, 13 C NMR, 1 H NMR, EI MS techniques. These compounds were investigated in vitro for their antimicrobial properties and several compounds have fungicidal activity against  Candida albicans and Saccharomyces cerevisiae . And also some of the compounds exhibited excellent activity on Mycobacterium smegmatis , a nonpigmented fast-rising mycobacterium, at the concentration of <1 μg/mL is better than standard drug streptomycin.
Keywords : 1, 2, 4 triazole, piperazine, conazole, mannich base, biological activity