Synthesis of Some New Benzimidazole Derivatives Containing Chlorine and Investigation of Their Antioxidant and Anti-urease Activities

Authors : Nesrin KARAALİ

Pages : 971-980

Doi:10.18596/jotcsa.440202

View : 16 | Download : 10

Publication Date : 2018-01-01

Article Type : Research Paper

Abstract :In this work, the synthesis of 2-substituted benzimidazole compound containing chlorine insert ignore into journalissuearticles values( 1 ); was carried out and then converted to the ester insert ignore into journalissuearticles values(2); and hydrazide insert ignore into journalissuearticles values(3); derivatives respectively. In the next steps, the hydrazide compound insert ignore into journalissuearticles values( 3 ); was reacted with the appropriate reagents to give the thiadiazole insert ignore into journalissuearticles values( 8-10 ); and triazole insert ignore into journalissuearticles values( 11-13 ); derivatives. Synthesis of the compound 4 was carried out as a result of the interaction of the ester derivative compound insert ignore into journalissuearticles values( 2 ); with morpholine. The structures of all synthesized compounds were elucidated by FT-IR, 1 H NMR, 13 C NMR and elemental analysis spectroscopic methods. Also, the antioxidant and urease enzyme inhibition properties of these compounds were also investigated.
Keywords : Benzimidazole, triazole, thiadiazole