Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode

Authors : Burçin BOZAL PALABIYIK

Pages : 751-758

Doi:10.18596/jotcsa.998696

View : 19 | Download : 12

Publication Date : 2022-08-31

Article Type : Research Paper

Abstract :This study aims to offer a voltammetric method for determining the antipsychotic drug flupentixol from serum samples. According to pH and scan rate studies, the oxidation behavior of flupentixol at boron-doped diamond electrode was found as irreversible and diffusion-controlled. In order to determine flupentixol from bulk form and serum samples, differential pulse voltammetry was preferred as the working method because of the repeatability. Linear responses were obtained in the range of 6.0×10-7 – 8.0×10-6 M and 8.0×10-7 – 1.0×10-5 M for bulk form and serum samples in pH 2.0 Britton-Robinson buffer solution, with detection limit values of 1.09×10-7 M and 1.08×10-7 M, respectively. Required validation parameters were also studied and according to recovery from serum samples insert ignore into journalissuearticles values(99.91 %); and precision studies, it can be said that developed method was accurate and precise.
Keywords : Flupentixol, voltammetry, boron doped diamond electrode, serum, validation