Novel Perylene-Based Antimicrobial PDI Chromophores

Authors : Cansu YILMAZ, Pınar GÜNER, Tülin AŞKUN, Funda YÜKRÜK

Pages : 633-640

Doi:10.18596/jotcsa.1292068

View : 65 | Download : 69

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :The main goal of the study was to monitor the Antimicrobial activity of two novel perylene diimides which were synthesized and characterized. Antimicrobial activity was investigated against Four Mycobacterium tuberculosis strains insert ignore into journalissuearticles values(MT); insert ignore into journalissuearticles values(Mt-H37Rv, Mt-H37Ra and two clinical isolates); and two Staphylococcus aureus strains [Methicillin-resistant Staphylococcus aureus insert ignore into journalissuearticles values(MRSA); and Staphylococcus aureus insert ignore into journalissuearticles values(SA);]. Minimum inhibitory concentrations insert ignore into journalissuearticles values(MICs); and minimum bactericidal activity insert ignore into journalissuearticles values(MBCs); were determined. Both compounds exhibited bactericidal effects and MICs were found to be changing in the range of 48-96 µg/mL for four MT-strains. Compounds were also effective on Staphylococcus strains at MIC = 96 µg/mL.
Keywords : Perylene diimide, Antimicrobial activity, Mycobacterium tuberculosis, Methicillin resistant, Staphylococcus aureus, MIC, MBC